Which of the following best describe the mechanism of calmodulin (CaM) mediated activation?
A) Ca2+ binding to calmodulin (CaM) results in conformational change that exposes a hydrophobic patch capable of binding to calcium sensitive protein kinase
B) a conformational change induced by the binding of Ca2+ results in the release of the phosphate group in calmodulin (CaM)
C) calmodulin (CaM) sensitive protein kinase dimerizes forming a joint active site capable of tightly binding Ca2+
D) phosphorylation of a tyrosine on calmodulin induced a conformational change that results in release of Ca2+ from the cytosol.
E) none of the above.
Answer: A) Ca2+ binding to calmodulin (CaM) results in conformational change that exposes a hydrophobic patch capable of binding to calcium sensitive protein kinase
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