Which of the following correctly ranks the steps in the secretory pathway?
1. Synthesis occurs with a leading signal peptide
2. The SRP-ribosome complex binds the SRP receptor-translocon complex
3. The signal peptide binds the SRP and GDP is replaced with GTP
4. GTP hydrolysis results in dissociation of SRP and SR
5. SRP changes in conformation arresting peptide growth
6. The nascent protein begins to fold and post-translational modification is initiated 7. Signal peptidase cleaves the protein from the signal peptide
A) 1, 2, 5, 4, 6, 7, 3
B) 1, 3, 5, 2, 4, 7, 6
C) 2, 4, 1, 3, 5, 6, 7
D) 2, 4, 3, 5, 4, 6, 7
E) 1, 3, 4, 2, 5, 7, 6
Answer: B) 1, 3, 5, 2, 4, 7, 6
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