In sickle-cell anemia, the negatively charged glutamic acid residue is replaced by the neutral amino acid ____________. 11:48 Animal Biology In sickle-cell anemia, the negatively charged glutamic acid residue is replaced by the neutral amino acid ____________. A) tyrosine B) lysine C) valine D) adenosine E) glycine Answer: C) valine Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+