How were Spemann and Mangold able to tell that the organizer was directing cells of the host embryo to change their fates?

How were Spemann and Mangold able to tell that the organizer was directing cells of the host embryo to change their fates?



A - They assumed that all cells were dividing at the same rate and therefore some cells from the host embryo had to change their fate; otherwise there just wouldn't be enough cells.
B - They sequenced the DNA from different cells so that they could tell the host cells from the graft cells based on genotype.
C - They carefully observed the embryos differentiating under the microscope and kept track of which cells became what
D - They injected the graft cells with a dye to mark them and their progeny
E - The host cells and the graft cells had different pigmentation


Answer: E - The host cells and the graft cells had different pigmentation


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