Methylation and acetylation are common changes made to histone H3, and the specific combination of these changes is sometimes referred to as the "histone code." Which of the following patterns will probably lead to gene silencing?
(a) lysine 9 methylation
(b) lysine 4 methylation and lysine 9 acetylation
(c) lysine 14 acetylation
(d) lysine 9 acetylation and lysine 14 acetylation
Answer: A