A strain of yeast translates mRNA into protein inaccurately. Individual molecules of a particular protein isolated from this yeast have variations in the first 11 amino acids compared with the sequence of the same protein isolated from normal yeast cells, as listed in Figure Q7-45. What is the most likely cause of this variation in protein sequence?
(a) a mutation in the DNA coding for the protein
(b) a mutation in the anticodon of the isoleucine-tRNA (tRNAIle)
(c) a mutation in the isoleucyl-tRNA synthetase that decreases its ability to distinguish between different amino acids
(d) a mutation in the isoleucyl-tRNA synthetase that decreases its ability to distinguish between different tRNA molecules
Answer: C